Publication Name	World Journal of Hepatology
Manuscript ID	118817
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Beyond fibrosis: The imperative for dual steatosis and fibrosis assessment in chronic hepatitis B and metabolic dysfunction-associated steatotic liver disease co-pathology
Manuscript Source	Invited Manuscript
All Author List	Francesco Giangregorio, Elisa Civaschi, Samanta Mazzocchi, Davide Romano, Paolo Clini, Esther Centenara, Umberto Casale and Davide Catucci
Funding Agency and Grant Number
Corresponding Author	Francesco Giangregorio, Associate Professor, Chief Physician, Director, Department of Internal Medicine, Val Tidone Hospital, Viale II Giugno 1, Castel San Giovanni 29015, Emilia-Romagna, Italy. f.giangregorio67@gmail.com
Key Words	Chronic hepatitis B; Metabolic dysfunction-associated steatotic liver disease; Liver fibrosis; Non-invasive tests; Transforming growth factor-β; L59 (LAP degradation product); Platelet count; Fibrogenesis
Core Tip	Non-invasive assessment of liver injury in chronic hepatitis B is evolving beyond static fibrosis markers toward biologically driven models. The L59-based nomogram proposed by Dai et al captures active fibrogenesis through transforming growth factor-βactivation, integrating molecular, inflammatory, and hematologic parameters. This approach is particularly relevant in patients with concurrent metabolic dysfunction-associated steatotic liver disease, where steatosis may be deceptively mild despite advanced fibrosis. A dual, non-invasive evaluation of fibrosis and steatosis is therefore essential to avoid underestimation of disease severity and to optimize risk stratification in dual-etiology liver disease.
Citation	Giangregorio F, Civaschi E, Mazzocchi S, Romano D, Clini P, Centenara E, Casale U, Catucci D. Beyond fibrosis: The imperative for dual steatosis and fibrosis assessment in chronic hepatitis B and metabolic dysfunction-associated steatotic liver disease co-pathology. World J Hepatol 2026; In press

Received	2026-01-12 01:47
Peer-Review Started	2026-01-12 01:47
First Decision by Editorial Office Director	2026-01-16 06:48
Return for Revision	2026-01-16 06:48
Revised	2026-01-20 22:10
Publication Fee Transferred
Second Decision by Editor	2026-02-11 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-11 09:16
Articles in Press	2026-02-11 09:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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