Publication Name	World Journal of Experimental Medicine
Manuscript ID	118828
Country	Türkiye

Category	Psychology, Experimental
Manuscript Type	Basic Study
Article Title	Comparison of ozone administration routes on liver, lung, and brain damage after spinal cord ischemia-reperfusion injury
Manuscript Source	Invited Manuscript
All Author List	Necmiye Şengel, Zeynep Köksal, Aysegül Küçük, Şaban Cem Sezen, Işın Güneş, Muharrem Atlı, Gülay Kip, Seda Gökgöz Acar, Abdullah Özer, Mustafa Kavutçu and Mustafa Arslan
Funding Agency and Grant Number
Corresponding Author	Necmiye Şengel, Assistant Professor, Department of Oral and Maxillofacial Surgery, Gazi University Faculty of Dentistry, Bişkek Cd.(8.Cd.) 1.Sk. No:8 06490 Emek, Ankara 06490, Türkiye. necmiyesengel@hotmail.com
Key Words	Spinal cord; Ischemia reperfusion; Liver; Lung; Brain; Ozone; Rat
Core Tip	Spinal cord ischemia-reperfusion injury (IRI) is a complex process affecting multiple organs. Current preventive strategies remain insufficient. This study investigated the protective effects of single-dose ozone pretreatment via intrathecal, intraperitoneal, and rectal routes on liver, lung, and brain tissues in a rat spinal cord IRI model. Histopathological results demonstrated that ozone pretreatment through all three routes significantly reduced oxidative damage and improved tissue outcomes compared to the IR group. Medical ozone administration may offer a viable therapeutic option with high efficacy and minimal side effects in preventing IRI-related organ damage.
Citation	Şengel N, Köksal Z, Küçük A, Sezen ŞC, Güneş I, Atlı M, Kip G, Gökgöz Acar S, Özer A, Kavutçu M, Arslan M. Comparison of ozone administration routes on liver, lung, and brain damage after spinal cord ischemia-reperfusion injury. World J Exp Med 2026; In press

Received	2026-01-12 01:41
Peer-Review Started	2026-01-12 01:42
First Decision by Editorial Office Director	2026-02-26 07:30
Return for Revision	2026-02-26 07:30
Revised	2026-03-11 18:03
Publication Fee Transferred
Second Decision by Editor	2026-05-11 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-11 07:31
Articles in Press	2026-05-11 07:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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