Publication Name	World Journal of Gastroenterology
Manuscript ID	118836
DOI	10.3748/wjg.118836
Country	Brazil

Category	Microbiology
Manuscript Type	Opinion Review
Article Title	Polyethylene glycol-based bowel preparation and gut dysbiosis: Clinical implications beyond colon cleansing
Manuscript Source	Invited Manuscript
All Author List	Ana Clara Correia Melgaço, Adriano Francisco Alves and Wallace Felipe Blohem Pessoa
Funding Agency and Grant Number
Corresponding Author	Wallace Felipe Blohem Pessoa, Adjunct Professor, PhD, Department of Biomedical Sciences, Federal University of Paraíba, Via Pau Brasil, S/N, João Pessoa, Paraíba, 58050-585, Brazil, João Pessoa 58050-585, Paraíba, Brazil. wall.bmd@gmail.com
Key Words	Polyethylene glycol; Dysbiosis; Bowel preparation; Microbiota; Mucosal recovery; Infection risk
Core Tip	Polyethylene glycol (PEG)-based bowel preparation may transiently alter gut microbial diversity, mucus barrier integrity, and short-chain fatty acid production. Although these ecological changes are increasingly associated with immune modulation and postoperative outcomes, current evidence remains heterogeneous and largely observational. Suitably, this opinion review critically examines the mechanisms and potential clinical implications of PEG-induced dysbiosis. The review also emphasizes the need for microbiota-preserving bowel preparation strategies and personalized approaches based on host resilience and baseline microbiota composition.
Citation	Melgaço ACC, Alves AF, Pessoa WFB. Polyethylene glycol-based bowel preparation and gut dysbiosis: Clinical implications beyond colon cleansing. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.118836
PDF	118836-in-press.pdf

Received	2026-01-20 01:31
Peer-Review Started	2026-01-20 01:32
First Decision by Editorial Office Director	2026-02-06 10:45
Return for Revision	2026-02-06 10:45
Revised	2026-02-16 01:28
Publication Fee Transferred
Second Decision by Editor	2026-06-09 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-09 07:25
Articles in Press	2026-06-09 07:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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