| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
FOLH1 as a novel biomarker for risk stratification in gastric intestinal metaplasia
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shan He, Xiao-Fei Guo, Yuan Wang, Jian-Qi Bai, Jian-Peng Wang, Jun-He Shi, Yang-Yi Shi, Jing Yuan, Wei Wei, Yang Yang, Xiao-Hua Shi, Yao Feng, Xia Ding, Wei Gao, Dan Lu, Wei-Xun Zhou and Ping Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| China Academy of Chinese Medical Sciences |
No. WJYY-XZKT-2023-07 |
| National Key Research and Development Program of China |
No. 2023YFC3503600 |
|
| Corresponding Author |
Ping Zhang, Full Professor, Department of Pathology, Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6 Huajiadi Street, Beijing 100016, China. pinglele@sina.com |
| Key Words |
Gastric intestinal metaplasia; Gastric cancer; Biomarker; Folate; FOLH1 |
| Core Tip |
In this study, digital spatial profiling was used to identify differentially expressed genes between progressive and nonprogressive gastric intestinal metaplasia (GIM). Among 14 candidate genes, FOLH1 showed the most significant difference. Validation in 60 patients using immunohistochemical and immunofluorescent staining confirmed that low FOLH1 expression strongly predicted progression, with excellent 4 diagnostic accuracy, establishing FOLH1 as a novel biomarker for risk stratification in GIM. |
| Citation |
He S, Guo XF, Wang Y, Bai JQ, Wang JP, Shi JH, Shi YY, Yuan J, Wei W, Yang Y, Shi XH, Feng Y, Ding X, Gao W, Lu D, Zhou WX, Zhang P. FOLH1 as a novel biomarker for risk stratification in gastric intestinal metaplasia. World J Gastroenterol 2026; In press |
