Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	118849
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	FNDC5 enhances quercetin-induced anoikis in pancreatic adenocarcinoma cells via focal adhesion kinase-dependent mechanisms
Manuscript Source	Unsolicited Manuscript
All Author List	Hui-Feng Gao, Ke Zhang, Chien-Shan Cheng, Ye-Hua Shen and Hao Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82074204
Corresponding Author	Hao Chen, Chief Physician, Department of Integrative Oncology, Fudan University Shanghai Cancer Center, No. 270 Dong’an Road, Shanghai 200032, China. chengkll@sina.com
Key Words	FNDC5; Irisin; Quercetin; Pancreatic ductal adenocarcinoma; Anoikis; Focal adhesion kinase; Mitochondrial apoptosis; Chemosensitivity
Core Tip	This study highlights that FNDC5 enhances quercetin-mediated growth inhibition, apoptosis, and anoikis through focal adhesion kinase/phosphatidylinositol 3-kinase/protein kinase B inhibition and mitochondrial apoptosis initiation. Our results provide further insight into the effect of irisin on pancreatic ductal adenocarcinoma (PAAD) cells and suggest a new strategy for PAAD treatment that combines quercetin and irisin.
Citation	Gao HF, Zhang K, Cheng CS, Shen YH, Chen H. FNDC5 enhances quercetin-induced anoikis in pancreatic adenocarcinoma cells via focal adhesion kinase-dependent mechanisms. World J Gastrointest Oncol 2026; In press

Received	2026-01-27 09:51
Peer-Review Started	2026-01-27 09:52
First Decision by Editorial Office Director	2026-02-10 09:01
Return for Revision	2026-02-10 09:01
Revised	2026-02-26 21:50
Publication Fee Transferred
Second Decision by Editor	2026-03-23 02:49
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-23 08:21
Articles in Press	2026-03-23 08:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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