Publication Name	World Journal of Psychiatry
Manuscript ID	118857
Country	China

Category	Psychology, Development
Manuscript Type	Retrospective Study
Article Title	Risk factors for anxiety and depression in patients with epilepsy and their relationship with quality of life
Manuscript Source	Unsolicited Manuscript
All Author List	Ning Zong, Xu-Ying Liu and Fang Chen
Funding Agency and Grant Number
Corresponding Author	Fang Chen, Associate Chief Nurse, Department of Nephrology, The Third Affiliated Hospital of Jinzhou Medical University, No. 2, Section 5, Heping Road, Linghe District, Jinzhou 121000, Liaoning Province, China. 18704162950@163.com
Key Words	Patients with epilepsy; Anxiety; Depression; Risk factors; Quality of life
Core Tip	This study identifies unemployment, high seizure frequency, polytherapy, and longer disease duration as key risk factors for anxiety and depression in Chinese patients with epilepsy. A clinical prediction model based on these factors effectively identifies high-risk individuals. Critically, comorbid anxiety and depression severely impair quality of life across all domains. These findings underscore the necessity of integrated care, combining optimized seizure control, medication review, and mental health support, to improve the holistic well-being of people living with epilepsy.
Citation	Zong N, Liu XY, Chen F. Risk factors for anxiety and depression in patients with epilepsy and their relationship with quality of life. World J Psychiatry 2026; In press

Received	2026-02-10 10:02
Peer-Review Started	2026-02-10 10:02
First Decision by Editorial Office Director	2026-03-03 07:25
Return for Revision	2026-03-03 07:25
Revised	2026-03-10 01:51
Publication Fee Transferred
Second Decision by Editor	2026-03-30 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-30 03:33
Articles in Press	2026-03-30 03:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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