Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	118861
Country	Lebanon

Category	Medicine, General & Internal
Manuscript Type	Minireviews
Article Title	Beyond intestinal failure: Expanding therapeutic frontiers of glucagon-like peptide-2 in gastrointestinal disease
Manuscript Source	Invited Manuscript
All Author List	Philippe Attieh, Dana Dabboussi, Wael Meraabi, Karam Karam, Rose Raymond Al Bacha and Bassam Abboud
Funding Agency and Grant Number
Corresponding Author	Bassam Abboud, Department of General Surgery, Geitaoui Hospital, Faculty of Medicine, Lebanese University, Rmeil, Beirut 16214, Lebanon. dbabboud@yahoo.fr
Key Words	Glucagon-like peptide-2; Short bowel syndrome; Intestinal failure; Teduglutide; Intestinal rehabilitation; Inflammatory bowel disease; Crohn’s disease
Core Tip	Short bowel syndrome is a life-threatening cause of intestinal failure traditionally managed with long-term parenteral nutrition. Recent advances highlight glucagon-like peptide-2 analogues as disease-modifying therapies that enhance intestinal adaptation rather than merely providing nutritional support. By stimulating mucosal growth, improving absorptive capacity, and strengthening the intestinal barrier, agents such as teduglutide and emerging long-acting analogues like glepaglutide significantly reduce parenteral nutrition dependence and improve quality of life. Beyond short bowel syndrome, accumulating evidence suggests anti-inflammatory and hepatoprotective benefits, supporting broader therapeutic potential. Ongoing research and long-term safety surveillance will be crucial to optimizing their clinical application.
Citation	Attieh P, Dabboussi D, Meraabi W, Karam K, Al Bacha RR, Abboud B. Beyond intestinal failure: Expanding therapeutic frontiers of glucagon-like peptide-2 in gastrointestinal disease. World J Gastrointest Pharmacol Ther 2026; In press

Received	2026-01-13 03:51
Peer-Review Started	2026-01-13 05:29
First Decision by Editorial Office Director	2026-01-29 09:17
Return for Revision	2026-01-29 09:17
Revised	2026-02-03 08:16
Publication Fee Transferred
Second Decision by Editor	2026-03-11 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-11 08:38
Articles in Press	2026-03-11 08:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
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