Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	118864
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Efficacy of thrombin spray combined with clip closure after colorectal endoscopic mucosal resection and endoscopic submucosal dissection
Manuscript Source	Unsolicited Manuscript
All Author List	Shi-Song Gu, Peng Zhang and Ke-Dong Zhu
Funding Agency and Grant Number
Corresponding Author	Ke-Dong Zhu, Department of Gastroenterology, The Affifiliated Chuzhou Hospital of Anhui Medical University (The First People’s Hospital of Chu Zhou), No. 369 Luwan West Road, Nanyin District, Chuzhou 239000, Anhui Province, China. 13955081226@163.com
Key Words	Endoscopic mucosal resection; Endoscopic submucosal dissection; Postoperative bleeding; Thrombin; Titanium clips; Hemostasis; Colorectal neoplasms
Core Tip	This study demonstrates that combining endoscopic thrombin powder spraying with titanium clip mechanical closure provides synergistic hemostasis for colorectal endoscopic mucosal resection and endoscopic submucosal dissection wounds. This dual strategy not only improves intraoperative bleeding control but also reduces postoperative pain, accelerates functional recovery, and enhances early postoperative quality of life without increasing complication risk. The findings suggest that chemical-mechanical hybrid wound management may represent a safer and more effective modality for preventing bleeding after advanced colorectal endoscopic resection.
Citation	Gu SS, Zhang P, Zhu KD. Efficacy of thrombin spray combined with clip closure after colorectal endoscopic mucosal resection and endoscopic submucosal dissection. World J Gastrointest Surg 2026; In press

Received	2026-02-06 09:58
Peer-Review Started	2026-02-06 09:58
First Decision by Editorial Office Director	2026-02-27 06:51
Return for Revision	2026-02-27 06:51
Revised	2026-03-19 14:58
Publication Fee Transferred	2026-03-23 06:12
Second Decision by Editor	2026-05-19 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-19 06:26
Articles in Press	2026-05-19 06:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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