Publication Name	World Journal of Psychiatry
Manuscript ID	118914
Country	China

Category	Psychology, Multidisciplinary
Manuscript Type	Opinion Review
Article Title	Integrating psychosocial and immune monitoring: A new pathway for managing depression in malignant melanoma
Manuscript Source	Invited Manuscript
All Author List	Jia-Wei Chen, Chuang Cai and Shu-Qi Ren
Funding Agency and Grant Number	Funding Agency Grant Number Zhongshan Science and Technology Bureau, China No. 2023B1033
Corresponding Author	Shu-Qi Ren, Associate Research Scientist, Department of Laboratory Medicine, Zhongshan City Hospital of Integration of TCM and Western Medicine, No. 10 Dexiu Road, Zhongshan 528467, Guangdong Province, China. shuchijen@163.com
Key Words	Malignant melanoma; Depression; Psychoneuroimmunology; Immune monitoring; Inflammatory biomarkers; Psycho-oncology; Integrated care
Core Tip	This article emphasizes that depression in malignant melanoma is not merely a psychological response but a systemic manifestation significantly associated with the tumor immune microenvironment. Integrating psychosocial evaluation with immune monitoring - using biomarkers such as interleukin-6, CD4⁺ count, and neutrophil-to-lymphocyte ratio - facilitates early risk stratification and timely intervention, which may concurrently improve mental health and immune function at the associative level and potentially influence disease prognosis.
Citation	Chen JW, Cai C, Ren SQ. Integrating psychosocial and immune monitoring: A new pathway for managing depression in malignant melanoma. World J Psychiatry 2026; In press

Received	2026-01-14 00:32
Peer-Review Started	2026-01-14 00:33
First Decision by Editorial Office Director	2026-02-03 07:34
Return for Revision	2026-02-03 07:34
Revised	2026-02-12 15:11
Publication Fee Transferred
Second Decision by Editor	2026-05-06 03:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-06 04:45
Articles in Press	2026-05-06 04:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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