Publication Name	World Journal of Gastroenterology
Manuscript ID	118939
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Gastric cancer-derived exosomal indoleamine 2,3 dioxygenase 1 drives immunosuppression in gastric cancer by suppressing dendritic cell maturation
Manuscript Source	Unsolicited Manuscript
All Author List	Yang-Yang Liu, Jun-Hua Ai, Le-Ming Zeng, Xue-Ni Liu and Fang Wu
Funding Agency and Grant Number	Funding Agency Grant Number General Project Funded by Jiangxi Provincial Natural Science Foundation No. 20232BAB206095
Corresponding Author	Fang Wu, Department of Oncology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1519 Dongyue Avenue, Nanchang 330000, Jiangxi Province, China. wf70601852@163.com
Key Words	Gastric cancer; Exosomal indoleamine 2,3 dioxygenase 1; Dendritic cells; Cytotoxic T cells; Immunosuppression
Core Tip	Gastric cancer-derived exosomal indoleamine 2,3 dioxygenase 1 (IDO1) suppresses dendritic cell (DC) maturation, thereby facilitating tumor immune evasion. This study demonstrates that IDO1 is upregulated in gastric cancer tissues and selectively enriched in tumor-derived exosomes. These IDO1-carrying exosomes are internalized by DCs, leading to downregulation of maturation markers [cluster of differentiation (CD) 80, CD86, major histocompatibility complex class II] and an immunosuppressive cytokine shift [decreased interleukin (IL)-12p70 (IL-12p70), increased IL-10]. Silencing IDO1 in exosomes reverses these effects and attenuates tumor growth in vivo. Our findings identify exosomal IDO1 as a key mediator of tumor-DC crosstalk and a promising therapeutic target in gastric cancer.
Citation	Liu YY, Ai JH, Zeng LM, Liu XN, Wu F. Gastric cancer-derived exosomal indoleamine 2,3 dioxygenase 1 drives immunosuppression in gastric cancer by suppressing dendritic cell maturation. World J Gastroenterol 2026; In press

Received	2026-02-03 09:54
Peer-Review Started	2026-02-03 09:54
First Decision by Editorial Office Director	2026-02-25 03:03
Return for Revision	2026-02-25 03:03
Revised	2026-03-10 06:59
Publication Fee Transferred	2026-03-16 06:55
Second Decision by Editor	2026-03-27 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-27 08:18
Articles in Press	2026-03-27 08:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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