Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	118940
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	ST2, PIVKA-II, CEA, CA125 and their combinations in elderly liver metastases cancers: Development of a diagnostic scoring model
Manuscript Source	Unsolicited Manuscript
All Author List	Yun Cheng, Yan-Sha Sun and Yong-Ming He
Funding Agency and Grant Number
Corresponding Author	Yun Cheng, Associate Chief Physician, Department of Integrated Traditional Chinese Medicine and Western, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, No. 42 Baiziting, Nanjing 210009, Jiangsu Province, China. chengyun_nj@163.com
Key Words	Soluble growth-stimulating gene 2; Protein induced by vitamin K absence or antagonist-II; Carcinoembryonic antigen; Carbohydrate antigen 125; Liver metastasis; Lung cancer; Colorectal cancer; Scoring model
Core Tip	Based on the logistic regression analysis, a risk scoring model incorporating soluble growth-stimulating gene 2, protein induced by vitamin K absence or antagonist-II, carcinoembryonic antigen, carbohydrate antigen 125, and fatty liver history was developed to predict liver metastasis in elderly colorectal and lung cancer patients. The soluble growth-stimulating gene 2 + protein induced by vitamin K absence or antagonist-II + carcinoembryonic antigen + carbohydrate antigen 125 combination achieved the optimal diagnostic balance (area under the curve = 0.896), with specificity reaching 98.42%. Risk stratification significantly correlated with metastasis incidence (93.2% in high-risk vs 10.4% in low-risk). This quantitative model provides a simple, non-invasive tool for early identification of high-risk patients, facilitating personalized surveillance and timely intervention.
Citation	Cheng Y, Sun YS, He YM. ST2, PIVKA-II, CEA, CA125 and their combinations in elderly liver metastases cancers: Development of a diagnostic scoring model. World J Gastrointest Oncol 2026; In press

Received	2026-01-30 09:48
Peer-Review Started	2026-01-30 09:48
First Decision by Editorial Office Director	2026-02-10 09:01
Return for Revision	2026-02-10 09:01
Revised	2026-02-12 12:12
Publication Fee Transferred
Second Decision by Editor	2026-04-01 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-01 06:45
Articles in Press	2026-04-01 06:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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