Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	119003
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Modified frailty index and systemic immune-inflammation enable biological risk stratification in geriatric colorectal cancer surgery
Manuscript Source	Invited Manuscript
All Author List	Kai-Zhen Xu, Wen-Jian Hu, Yu-Hui Shang, Yan-Dong Miao and Li-Na Wang
Funding Agency and Grant Number	Funding Agency Grant Number Shandong Province Medical and Health Science and Technology Development Plan Project 202203030713, 202303031093 Shandong Province Medical and Health Science and Technology Development Plan Project 202503110210, and 202509030205 Yantai Science and Technology Program 2024YD010 Science and Technology Program of Yantai affiliated Hospital of Binzhou Medical University YTFY2022KYQD06 Twenty-First Century Public Welfare Foundation Academic Research Project JJH2025001 and JJH2025002
Corresponding Author	Li-Na Wang, Associate Chief Physician, Associate Professor, Deputy Director, Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, No. 717 Jinbu Street, Muping District, Yantai 264100, Shandong Province, China. 786130430@qq.com
Key Words	Colorectal cancer; Older adults; Modified frailty index; Systemic immune-inflammation index; Biological risk stratification; Postoperative complications; Recurrence-free survival
Core Tip	Chronological age alone poorly captures operative risk in older adults with colorectal cancer. Integrating the modified frailty index with the systemic immune-inflammation index (platelet count × neutrophil count/lymphocyte count) enables biological risk stratification that better predicts postoperative complications and recurrence-free survival. This combined framework links frailty-related loss of physiological reserve with inflammaging-driven immune dysregulation, clarifying why vulnerable patients deteriorate after surgical stress and supporting individualized decisions, targeted prehabilitation, and intensified perioperative surveillance.
Citation	Xu KZ, Hu WJ, Shang YH, Miao YD, Wang LN. Modified frailty index and systemic immune-inflammation enable biological risk stratification in geriatric colorectal cancer surgery. World J Gastrointest Oncol 2026; In press

Received	2026-01-16 05:55
Peer-Review Started	2026-01-16 05:55
First Decision by Editorial Office Director	2026-01-21 06:53
Return for Revision	2026-01-21 06:53
Revised	2026-01-29 02:30
Publication Fee Transferred
Second Decision by Editor	2026-02-09 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-09 08:05
Articles in Press	2026-02-09 08:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com