Publication Name	World Journal of Gastroenterology
Manuscript ID	119006
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Chronic ulcer diagnosis and perforation risk with oral agent contrast-enhanced ultrasound: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Man-Li Wei and Qing-Lan Tan
Funding Agency and Grant Number	Funding Agency Grant Number Youth Fund for Self-Financed Scientific Research Projects of the Guangxi Zhuang Autonomous Region Health Commission Z20190921
Corresponding Author	Man-Li Wei, Associate Chief Physician, Department of Ultrasound Medicine, The First People's Hospital of Nanning, No. 89, Qixing Road, Qingxiu District, Nanning 530021, Guangxi Zhuang Autonomous Region, China. 260077529@qq.com
Key Words	Gastric ulcer; Multidisciplinary treatment; Hepatocellular carcinoma; Oral agent; Ultrasound; Perforation; Case report
Core Tip	Gastric perforation is a rare yet severe complication of abdominal radiotherapy, occurring more frequently when combined immunotherapy and tyrosine kinase inhibitor therapy are administered. Most patients require emergency surgical intervention. This study reports a case where, within the complex context of comprehensive hepatocellular carcinoma treatment (involving radiotherapy, chemotherapy, immunotherapy, and targeted therapy), traditional methods (gastroscopy, contrast-enhanced computed tomography) could not accurately assess ulcer infiltration depth due to blood crust coverage and gastric wall edema. Oral agent contrast-enhanced ultrasound as a novel monitoring tool, clearly demonstrated that the ulcer had reached the serosal layer, thereby successfully predicting impending perforation.
Citation	Wei ML, Tan QL. Chronic ulcer diagnosis and perforation risk with oral agent contrast-enhanced ultrasound: A case report and review of literature. World J Gastroenterol 2026; In press

Received	2026-01-29 03:35
Peer-Review Started	2026-01-29 03:35
First Decision by Editorial Office Director	2026-02-13 08:20
Return for Revision	2026-02-13 08:20
Revised	2026-02-27 05:35
Publication Fee Transferred	2026-03-03 14:35
Second Decision by Editor	2026-03-18 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-18 05:45
Articles in Press	2026-03-18 05:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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