| Category |
Transplantation |
| Manuscript Type |
Minireviews |
| Article Title |
Combined liver-kidney transplantation in polycystic disease: Our experience and literature review
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Alessandro Tropea, Duilio Pagano, Salvatore Piazza, Sergio Calamia, Sergio Li Petri, Fabrizio di Francesco, Pasquale Bonsignore, Irene Vitale, Ivan Vella, Caterina Accardo, Federica Chimenti, Paola Salis, Barbara Buscemi, Xing Lai, Alessandro Mattina and Salvatore Gruttadauria |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Alessandro Tropea, MD, PhD, Abdominal Center, IRCCS ISMETT, Via E. Tricomi, 5, Palermo 90127, Italy. atropea@ismett.edu |
| Key Words |
Combined liver-kidney transplantation; Liver transplant; Hypothermic machine perfusion; Polycistic disease; End-stage renal disease; Chronic liver disease; Cirrhosis |
| Core Tip |
Polycystic liver–kidney disease is a rare but debilitating condition requiring combined liver–kidney transplantation (CLKT). This evidence review integrates contemporary data with our single-centre series (ISMETT, 2008–2025) of 20 CLKTs for polycystic disease. The results show 95% patient survival (95% C.I.: 86─100%) at 1, 3, and 5 years after transplant and two lost kidney graft. We summarise actionable selection and technical considerations, such as symptom-driven liver listing, renal trajectory, and selective native nephrectomy, and emphasise innovations including liver-mediated immunoprotection and hypothermic machine perfusion, which enable delayed kidney implantation and the safer use of extended-criteria donors. |
| Citation |
Tropea A, Pagano D, Piazza S, Calamia S, Li Petri S, di Francesco F, Bonsignore P, Vitale I, Vella I, Accardo C, Chimenti F, Salis P, Buscemi B, Lai X, Mattina A, Gruttadauria S. Combined liver-kidney transplantation in polycystic disease: Our experience and literature review. World J Gastrointest Surg 2026; In press |
