Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	119026
DOI	10.4251/wjgo.119026
Country	China

Category	Medicine, General & Internal
Manuscript Type	Basic Study
Article Title	Polymerase chain reaction detection of Streptococcus anginosus in digestive diseases and its immunomodulation in rat gastric cancer model
Manuscript Source	Unsolicited Manuscript
All Author List	Dong-Biao Huang, Bai-Song Chen, Ai-Ping Wang, Xiu-Zhen Hu and Ye-Jin Xu
Funding Agency and Grant Number
Corresponding Author	Ye-Jin Xu, Chief Physician, Departmeng of Infectious Diseases, Jinhua Municipal Central Hospital, No. 365 Renmin East Road, Jinhua 321000, Zhejiang Province, China. xuyejinfox@163.com
Key Words	Streptococcus anginosus; Polymerase chain reaction; Digestive tract neoplasms; Gastric cancer; Interleukin-6; Tumor necrosis factor-α; Immune cell infiltration
Core Tip	This study characterizes Streptococcus anginosus (S. anginosus) colonization across digestive diseases and its immunomodulatory role in gastric cancer. In a prospective cohort of 93 patients, S. anginosus positivity and relative load were highest in malignant tumors. Using a chemically induced gastric cancer rat model, S. anginosus colonization was shown to promote tumor progression, elevate serum interleukin-6 and tumor necrosis factor-α levels, and enhance infiltration of CD4+, CD8+ T cells, and CD68+ macrophages. The findings indicate that S. anginosus remodels the tumor immune microenvironment to favor carcinogenesis, suggesting its potential as a microbial and immunotherapeutic target.
Citation	Huang DB, Chen BS, Wang AP, Hu XZ, Xu YJ. Polymerase chain reaction detection of Streptococcus anginosus in digestive diseases and its immunomodulation in rat gastric cancer model. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.119026
PDF	119026-in-press.pdf

Received	2026-02-06 10:06
Peer-Review Started	2026-02-06 10:06
First Decision by Editorial Office Director	2026-02-25 02:53
Return for Revision	2026-02-25 02:53
Revised	2026-03-11 09:39
Publication Fee Transferred	2026-03-23 09:03
Second Decision by Editor	2026-06-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-22 07:53
Articles in Press	2026-06-22 07:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com