Publication Name	World Journal of Gastroenterology
Manuscript ID	119060
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Precise phenotyping clarifies uric acid-to-high-density lipoprotein cholesterol ratio for cardiovascular risk in metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Peng-Mei Zhou, Chao-Ting Yang, Jian-Feng Bao and Jin-Song Huang
Funding Agency and Grant Number
Corresponding Author	Jin-Song Huang, Department of Hepatology, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, No. 2 Hengbu Road, Hangzhou 310023, Zhejiang Province, China. huangjinsongyz@126.com
Key Words	Metabolic dysfunction-associated steatotic liver disease; Cardiovascular risk; Uric acid-to-high-density lipoprotein cholesterol ratio; Phenotypic heterogeneity; Risk stratification; Noninvasive assessment
Core Tip	The diagnosis of ultrasonography-based metabolic dysfunction-associated steatotic liver disease overlooks hepatic phenotypic heterogeneity and the shared inflammatory metabolic mechanisms of the cardiohepatic axis, potentially confounding the association between uric acid-to-high-density lipoprotein cholesterol ratio (UHR) and cardiovascular disease risk. We argue that precise phenotyping, namely quantification of steatosis using the controlled attenuation parameter or magnetic resonance imaging proton-density fat fraction and staging fibrosis using vibration-controlled transient elastography, is essential to determine whether UHR is an independent predictor of cardiovascular disease risk, thereby clarifying whether UHR is a general biomarker or an indicator of high-risk patients requiring integrated cardiometabolic–hepatic management.
Citation	Zhou PM, Yang CT, Bao JF, Huang JS. Letter to the Editor: Precise phenotyping clarifies uric acid-to-high-density lipoprotein cholesterol ratio for cardiovascular risk in metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; In press

Received	2026-01-26 06:53
Peer-Review Started	2026-01-26 06:54
First Decision by Editorial Office Director	2026-02-09 09:47
Return for Revision	2026-02-09 09:47
Revised	2026-02-18 16:55
Publication Fee Transferred
Second Decision by Editor	2026-04-07 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-07 10:15
Articles in Press	2026-04-07 10:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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