Publication Name	World Journal of Psychiatry
Manuscript ID	119077
Country	China

Category	Psychiatry
Manuscript Type	Opinion Review
Article Title	Serum serotonin as a unifying biomarker for dyskinesia and depression in Parkinson’s disease
Manuscript Source	Invited Manuscript
All Author List	Juan Yan, Hao-Yu Xing, Wen-Ye Wu, Jun-Jie Wang, Kai-Jie Fang and Fu-Gang Luo
Funding Agency and Grant Number
Corresponding Author	Fu-Gang Luo, Chief Physician, Head, Professor, Department of Intensive Care Unit, Mental Health Center Affiliated to Zhejiang University School of Medicine/Hangzhou Seventh People’s Hospital, No. 305 Tianmushan Road, Xihu District, Hangzhou 310013, Zhejiang Province, China. luofugang123123@163.com
Key Words	Parkinson’s disease; Serotonin; 5-Hydroxytryptamine; Biomarkers; Dyskinesia; Depression; Levodopa-induced dyskinesia; Non-motor symptoms; Precision medicine; Neurotransmitter
Core Tip	This review synthesizes evidence suggesting that serum serotonin (5-hydroxytryptamine) may serve as an accessible biomarker linking levodopa-induced dyskinesia and depression in Parkinson’s disease. Reduced peripheral serotonin levels are associated with both conditions and may reflect shared central serotonergic dysfunction. Yet the relationship between peripheral and central measures -and the biomarker’s predictive specificity-remains unclear. That clarity will require validation through longitudinal, multimodal, and interventional studies. If confirmed, serum serotonin may support early risk identification and guide personalized therapeutic strategies.
Citation	Yan J, Xing HY, Wu WY, Wang JJ, Fang KJ, Luo FG. Serum serotonin as a unifying biomarker for dyskinesia and depression in Parkinson’s disease. World J Psychiatry; In Press

Received	2026-01-19 01:58
Peer-Review Started	2026-01-19 01:58
First Decision by Editorial Office Director	2026-02-26 06:34
Return for Revision	2026-02-26 06:34
Revised	2026-03-04 02:45
Publication Fee Transferred
Second Decision by Editor	2026-05-27 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-27 03:45
Articles in Press	2026-05-27 03:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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