Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	119082
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Pathological characteristics of hepatocellular carcinoma: A dual-center correlation analysis and validation
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Bo Huang, Ying-Dan Zhang, Jie Yang, Ying-Ying Huang, Li-Feng Huang, Shuang-Yue Wang, Wei Lu, Ze-He Huang and Ke Ding
Funding Agency and Grant Number	Funding Agency Grant Number Self-raised Research Projects from the Health Commission of Guangxi Zhuang Autonomous Region, China No. Z20200953
Corresponding Author	Ke Ding, Department of Radiology, The Third Affiliated Hospital of Guangxi Medical University, No. 13 Dancun Road, Nanning 530031, Guangxi Zhuang Autonomous Region, China. 272480365@qq.com
Key Words	Hepatocellular carcinoma; Edmondson-Steiner grading; Ki-67; Microvascular invasion; Satellite nodule; Biomarker
Core Tip	This dual-center retrospective study validates a tightly linked aggressive pathological cluster (Edmondson grade, microvascular invasion, satellite nodules, Ki-67) in hepatocellular carcinoma. We identify Ki-67 as a core, reproducible biomarker, with a validated cutoff of 32.5% demonstrating high specificity (0.813) for predicting satellite nodules positivity across two independent centers. These findings provide multicenter pathological evidence to inform postoperative risk stratification and adjuvant therapy decisions.
Citation	Huang HB, Zhang YD, Yang J, Huang YY, Huang LF, Wang SY, Lu W, Huang ZH, Ding K. Pathological characteristics of hepatocellular carcinoma: A dual-center correlation analysis and validation. World J Gastrointest Oncol 2026; In press

Received	2026-01-26 06:26
Peer-Review Started	2026-01-26 06:26
First Decision by Editorial Office Director	2026-03-13 10:20
Return for Revision	2026-03-13 13:43
Revised	2026-03-28 15:43
Publication Fee Transferred
Second Decision by Editor	2026-05-14 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-14 03:46
Articles in Press	2026-05-14 03:46
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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