Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	119098
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Beyond the mechanism: MiR-206 as a prognostic biomarker and therapeutic target in hepatocellular carcinoma after incomplete radiofrequency ablation
Manuscript Source	Invited Manuscript
All Author List	Yan Xu, Xiao-Bing Huang and Yong-Gang He
Funding Agency and Grant Number
Corresponding Author	Yong-Gang He, Associate Chief Physician, Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Army Medical University, No. 83 Xinqiaozheng Street, Shapingba District, Chongqing 400037, China. xqyyhyg@tmmu.edu.cn
Key Words	MicroRNA-206; Hepatocellular carcinoma; Radiofrequency ablation; Prognostic biomarker; Nanotherapy; Precision medicine
Core Tip	This commentary extends the findings from a recent article by proposing two concrete translational applications for microRNA-206 in the management of hepatocellular carcinoma: (1) As a preoperative biomarker to stratify recurrence risk before ablation; and (2) As a therapeutic agent administered locally by a nanocarrier during or after radiofrequency ablation to prevent recurrence. The potential duality of microRNA-206 could transform the standard of care for patients with high-risk hepatocellular carcinoma.
Citation	Xu Y, Huang XB, He YG. Letter to the Editor: Beyond the mechanism: MiR-206 as a prognostic biomarker and therapeutic target in hepatocellular carcinoma after incomplete radiofrequency ablation. World J Gastrointest Oncol 2026; In press

Received	2026-01-26 00:43
Peer-Review Started	2026-01-26 00:45
First Decision by Editorial Office Director	2026-02-02 08:56
Return for Revision	2026-02-02 08:56
Revised	2026-02-11 14:30
Publication Fee Transferred
Second Decision by Editor	2026-04-13 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-13 09:36
Articles in Press	2026-04-13 09:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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