Publication Name	World Journal of Cardiology
Manuscript ID	119100
Country	United States

Category	Pharmacology & Pharmacy
Manuscript Type	Meta-Analysis
Article Title	Cardiovascular safety of proton pump inhibitors in post-percutaneous coronary intervention patients receiving dual antiplatelet therapy: A meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Rohab Sohail, Zaraq Khan, Haider Hussain Shah, Ridda Khattak, Azeem Khan, Shahryar Chaudhry, Uzair Khan, Hafsa Mansoor, Fnu Namal, Jason Orciuolo, Sahil Desai and Manjeet Singh
Funding Agency and Grant Number
Corresponding Author	Rohab Sohail, MD, Internal Medicine, Bayhealth Medical Center, 640 South State Street, Dover, DE 19904, United States. rohabsohail98@gmail.com
Key Words	Proton pump inhibitors; Dual antiplatelet therapy; Percutaneous coronary intervention; Major cardiovascular adverse events; Cardiac revascularization
Core Tip	This meta-analysis provides a robust, clinically relevant evaluation of proton pump inhibitor use in patients receiving dual antiplatelet therapy after PCI by integrating evidence from both randomized trials and real-world observational studies. Importantly, it demonstrates that concerns regarding impaired antiplatelet efficacy do not translate into increased risks of acute coronary syndrome, mortality, stent thrombosis, or stroke in randomized data, suggesting that adverse signals seen in observational studies likely reflect residual confounding rather than true harm. These findings shift the focus from theoretical drug–drug interactions to patient-centered clinical outcomes and support the safe, guideline-concordant use of PPIs for gastrointestinal protection in appropriately selected post-PCI patients.
Citation	Sohail R, Khan Z, Shah HH, Khattak R, Khan A, Chaudhry S, Khan U, Mansoor H, Namal F, Orciuolo J, Desai S, Singh M. Cardiovascular safety of proton pump inhibitors in post-percutaneous coronary intervention patients receiving dual antiplatelet therapy: A meta-analysis. World J Cardiol 2026; In press

Received	2026-01-19 03:45
Peer-Review Started	2026-01-19 10:15
First Decision by Editorial Office Director	2026-02-02 08:58
Return for Revision	2026-02-02 08:58
Revised	2026-02-10 23:36
Publication Fee Transferred	2026-02-12 20:12
Second Decision by Editor	2026-04-01 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-01 07:49
Articles in Press	2026-04-01 07:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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