Publication Name	World Journal of Stem Cells
Manuscript ID	119118
Country	China

Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Basic Study
Article Title	Selenoprotein P attenuates oxidative senescence and ferroptosis-associated lipid peroxidation in dental pulp stem cells through a FOXM1-dependent program
Manuscript Source	Unsolicited Manuscript
All Author List	Ruo-Qi Zhang, Wei-Hao Chu, Jun-Bo Bai, Yong-Hua Lei and Dai Zhou
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82201771 Natural Science Foundation of Hunan Province 2024JJ6083 Health Research Project of Hunan Provincial Health Commission W20243143 Natural Science Foundation of Changsha kq2202491
Corresponding Author	Dai Zhou, Full Professor, PhD, Post Doctoral Researcher, Changsha Hospital for Maternal and Child Health Care, Hunan Normal University, No. 416 Chengnan Road, Changsha 410000, Hunan Province, China. zhoudai@hunnu.edu.cn
Key Words	Dental pulp stem cells; Aging; Selenoprotein P; Selenium; Oxidative stress; Ferroptosis; Forkhead box protein M1
Core Tip	Aging-associated decline of dental pulp stem cells is linked to impaired selenium-dependent antioxidant defense. This study integrates single-cell transcriptomics, oxidative stress modeling, and human tissue validation to show that selenoprotein P and sodium selenite co-treatment reduces senescence and ferroptosis-associated lipid peroxidation in dental pulp stem cells. The combined treatment is more effective than either agent alone, and ferrostatin-1 rescue supports ferroptosis-related injury involvement. Transcriptomic and knockdown analyses identify a forkhead box protein M1-dependent protective program downstream of selenoprotein P/selenium support, highlighting a candidate strategy for preserving dental pulp vitality during aging.
Citation	Zhang RQ, Chu WH, Bai JB, Lei YH, Zhou D. Selenoprotein P attenuates oxidative senescence and ferroptosis-associated lipid peroxidation in dental pulp stem cells through a FOXM1-dependent program. World J Stem Cells 2026; In press

Received	2026-01-20 07:17
Peer-Review Started	2026-01-20 08:28
First Decision by Editorial Office Director	2026-02-10 09:20
Return for Revision	2026-02-10 09:20
Revised	2026-02-21 09:47
Publication Fee Transferred	2026-02-26 05:50
Second Decision by Editor	2026-03-26 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-02 06:25
Articles in Press	2026-04-02 06:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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