Publication Name	World Journal of Stem Cells
Manuscript ID	119123
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Expression of liver cancer stem cell markers and association with recurrence and survival in hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Xing-Qing Jia, Shuai Han, Yan-Sheng Shang, Fan-Guo Kong, Lin Qi, Cheng-Liang Wang and Wu-Jun Xiong
Funding Agency and Grant Number	Funding Agency Grant Number Clinical Medicine Emerging Specialty (or Specific Disease) Program of the Pudong New Area Health Commission 2025-PWXZ-05 Science and Technology Development Fund of Shanghai Pudong New Area PKJ2024-Y54
Corresponding Author	Wu-Jun Xiong, MD, Department of Gastroenterology, Fudan University Affiliated Pudong Hospital, No. 2800 Gongwei Road, Huinan Town, Pudong New Area, Shanghai 201399, China. xiongwujun25@163.com
Key Words	Hepatocellular carcinoma; Cancer stem cells; EpCAM; CD133; CK19; CD44; Recurrence; Prognosis
Core Tip	Postoperative recurrence is common after curative resection of hepatocellular carcinoma, highlighting the need for improved tissue-based risk stratification. We assessed four cancer stem cell-associated markers (EpCAM, CD133, CK19, and CD44) by immunohistochemistry in resected hepatocellular carcinoma. CK19 and CD133 were identified to carry prognostic information, and combined multi-marker assessment improved risk discrimination beyond routine clinicopathological factors. immunohistochemistry-based cancer stem cell profiling may help identify patients who require intensified surveillance and individualized postoperative management.
Citation	Jia XQ, Han S, Shang YS, Kong FG, Qi L, Wang CL, Xiong WJ. Expression of liver cancer stem cell markers and association with recurrence and survival in hepatocellular carcinoma. World J Stem Cells 2026; In press

Received	2026-01-27 09:53
Peer-Review Started	2026-01-27 09:53
First Decision by Editorial Office Director	2026-02-14 07:20
Return for Revision	2026-02-14 07:20
Revised	2026-03-02 03:57
Publication Fee Transferred	2026-03-12 15:15
Second Decision by Editor	2026-03-30 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-07 11:14
Articles in Press	2026-04-07 11:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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