Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	119140
DOI	10.4251/wjgo.119140
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Association between lymphopenia and the survival of patients with colorectal cancer: A meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Kai Chen, Hang Li and Han-He Chen
Funding Agency and Grant Number
Corresponding Author	Kai Chen, Researcher, Department of Gastrointestinal Surgery, The Affiliated Hospital of Putian University, No. 999 Dongzhen East Road, Licheng District, Putian 351100, Fujian Province, China. chenkaipt@163.com
Key Words	Colorectal cancer; Lymphopenia; Absolute lymphocyte count; Survival; Progression; Meta-analysis
Core Tip	This meta-analysis synthesized evidence from 13 retrospective cohort studies involving 3383 patients with colorectal cancer (CRC) to clarify the prognostic significance of lymphopenia. Both pretreatment and treatment-related lymphopenia were significantly associated with poorer progression-free and overall survival. Notably, treatment-related lymphopenia and lower absolute lymphocyte count cutoffs showed stronger associations with disease progression. These findings highlight lymphopenia as a simple, readily available immune biomarker for risk stratification and prognosis assessment in CRC, supporting closer lymphocyte monitoring during clinical management.
Citation	Chen K, Li H, Chen HH. Association between lymphopenia and the survival of patients with colorectal cancer: A meta-analysis. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.119140
PDF	119140-in-press.pdf

Received	2026-01-20 03:27
Peer-Review Started	2026-01-20 05:45
First Decision by Editorial Office Director	2026-02-02 08:56
Return for Revision	2026-02-02 08:56
Revised	2026-03-13 11:59
Publication Fee Transferred
Second Decision by Editor	2026-06-16 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-16 07:22
Articles in Press	2026-06-16 07:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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