Publication Name	World Journal of Clinical Oncology
Manuscript ID	119152
Country	China

Category	Immunology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Reovirus as an immunomodulatory adjuvant in KRAS-mutant colorectal cancer - translational insights and future directions
Manuscript Source	Invited Manuscript
All Author List	Xin-Lei Zhou, Fan Chen and Kai-Bo Guo
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Zhejiang Province, China ZCLQ24H2901 National Natural Science Foundation of China 82405093 Medical and Health Technology Program of Zhejiang Province, China 2024KY1328 Traditional Chinese Medicine Science and Technology Program of Zhejiang Province, China 2024ZL712
Corresponding Author	Kai-Bo Guo, MD, Department of Oncology, Affiliated Hangzhou First People's Hospital , School of Medicine, Westlake University, No. 261 Huansha Road, Hangzhou 310006, Zhejiang Province, China. guokaibo@zcmu.edu.cn
Key Words	Reovirus; KRAS mutation; Immune modulation; Tumor microenvironment; Metastatic colorectal cancer; Signaling pathway; Cytokine
Core Tip	This study discussed that reovirus affects gene expression and cytokine secretion by regulating phosphatidylinositol 3-kinase/protein kinase B and other signaling pathways, thereby regulating the immune system and ultimately exerting an anti-KRAS mutant colon cancer effect. The letter proposes to more accurately elucidate the local immune regulation mechanism of reovirus through large-scale, multi-center randomized controlled trials, combined with tumor microenvironment analysis and combined immunotherapy design, and enrich experimental analysis methods, laying a good foundation for clinical application of reovirus.
Citation	Zhou XL, Chen F, Guo KB. Letter to the Editor: Reovirus as an immunomodulatory adjuvant in KRAS-mutant colorectal cancer - translational insights and future directions. World J Clin Oncol 2026; In press

Received	2026-01-22 02:04
Peer-Review Started	2026-01-22 02:05
First Decision by Editorial Office Director	2026-02-25 07:57
Return for Revision	2026-02-25 07:57
Revised	2026-03-10 15:37
Publication Fee Transferred
Second Decision by Editor	2026-04-20 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-20 08:11
Articles in Press	2026-04-20 08:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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