Publication Name	World Journal of Diabetes
Manuscript ID	119203
DOI	10.4239/wjd.119203
Country	United States

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Severe insulin-deficient diabetes: Updated review of epidemiology, biology, and clinical implications
Manuscript Source	Unsolicited Manuscript
All Author List	Yara S Beyh, K M Venkat Narayan and Ram Jagannathan
Funding Agency and Grant Number	Funding Agency Grant Number National Heart, Lung, and Blood Institute No. P01HL154996 National Institute of Diabetes and Digestive and Kidney Diseases No. R01-DK139632
Corresponding Author	Yara S Beyh, PhD, Post Doctoral Researcher, Postdoc, Postdoctoral Fellow, Emory Global Diabetes Research Center, Hubert Department of Global Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30322, United States. ybeyh@emory.edu
Key Words	Type 2 diabetes; Severe insulin-deficient diabetes; Insulin deficiency; Insulin resistance; Beta-cell function
Core Tip	Severe insulin-deficient diabetes (SIDD) is a reproducible, non-autoimmune subtype of type 2 diabetes defined by profound β-cell dysfunction, marked hyperglycemia, and relatively lower body mass index. This review synthesizes global evidence showing that SIDD carries disproportionate microvascular risk particularly retinopathy and often requires early treatment intensification with frequent insulin use. A key innovation is highlighting population-specific subtype distributions, with insulin-deficient phenotypes more common in South Asians and linked to emerging signals for higher mortality and excess life-years lost. We integrate genetic and multi-omic insights implicating β-cell stress pathways and outline priorities for electronic health record-ready classification and subtype-guided trials.
Citation	Beyh YS, Narayan KMV, Jagannathan R. Severe insulin-deficient diabetes: Updated review of epidemiology, biology, and clinical implications. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.119203
PDF	119203-in-press.pdf

Received	2026-01-21 00:25
Peer-Review Started	2026-01-29 09:15
First Decision by Editorial Office Director	2026-03-04 08:54
Return for Revision	2026-03-04 08:54
Revised	2026-05-22 11:16
Publication Fee Transferred	2026-06-11 01:55
Second Decision by Editor	2026-07-14 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-14 08:14
Articles in Press	2026-07-14 08:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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