Publication Name	World Journal of Gastroenterology
Manuscript ID	119222
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Limosilactobacillus reuteri DSM 17938 and PTA 6475 as adjunct in Helicobacter pylori therapy: Systematic review and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Ruggiero Francavilla, Andrea Iannone, Fernanda Cristofori, Alessia Cafforio, Vanessa N Dargenio, Giovanni La Grasta, Viviana F Brindicci, Stefania P Castellaneta and Michele Barone
Funding Agency and Grant Number
Corresponding Author	Ruggiero Francavilla, Full Professor, MD, PhD, Interdisciplinary Department of Medicine, Pediatric Section, Children’s Hospital ‘Giovanni XXIII’, University of Bari “Aldo Moro”, Via Giovanni Amendola, 207, Bari 70126, Puglia, Italy. ruggiero.francavilla@uniba.it
Key Words	Helicobacter pylori; Limosilactobacillus reuteri; DSM 17938; PTA 6475; Probiotics; Antibiotic-associated side effects; Meta-analysis
Core Tip	Helicobacter pylori (H. pylori) eradication therapy often causes multiple gastrointestinal side effects, limiting adherence. Probiotics, particularly Limosilactobacillus reuteri (L. reuteri), have been suggested as adjuncts to improve tolerability during standard eradication regimens. Our meta-analysis showed L. reuteri supplementation significantly reduced diarrhea, nausea, and dysgeusia during eradication therapy, though without enhancing eradication rates. Benefits were consistent and clinically meaningful across randomized trials. Precision probiotics, such as L. reuteri DSM 17938, may improve patient comfort, adherence, and treatment continuity by reducing side effects, representing a promising supportive strategy in H. pylori management.
Citation	Francavilla R, Iannone A, Cristofori F, Cafforio A, Dargenio VN, La Grasta G, Brindicci VF, Castellaneta SP, Barone M. Limosilactobacillus reuteri DSM 17938 and PTA 6475 as adjunct in Helicobacter pylori therapy: Systematic review and meta-analysis. World J Gastroenterol 2026; In press

Received	2026-01-22 02:43
Peer-Review Started	2026-01-22 02:43
First Decision by Editorial Office Director	2026-02-13 08:13
Return for Revision	2026-02-13 08:13
Revised	2026-02-27 21:53
Publication Fee Transferred
Second Decision by Editor	2026-04-23 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-23 08:43
Articles in Press	2026-04-23 08:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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