Publication Name	World Journal of Stem Cells
Manuscript ID	119228
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Tongxie Yaofang enhances the homing efficiency of exogenous bone marrow-derived mesenchymal stem cells to the colonic mucosa and alleviates ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Shan-Shan Gong, Meng-Lin Li, Liu Liu and Bin Lv
Funding Agency and Grant Number	Funding Agency Grant Number Basic Public Welfare Research Program of Zhejiang Province LQ23H270008
Corresponding Author	Bin Lv, PhD, Professor, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Shangcheng District, Hangzhou 310000, Zhejiang Province, China. lvbin@medmail.com.cn
Key Words	Ulcerative colitis; Tongxie Yaofang; Bone marrow-derived mesenchymal stem cells; Stromal cell-derived factor 1; C-X-C motif chemokine ligand 12; C-X-C chemokine receptor type 4; Inflammatory bowel disease; Intestinal mucosal barrier; Traditional Chinese medicine; Migration
Core Tip	Bone marrow-derived mesenchymal stem cells (BMSCs) are a promising therapy for ulcerative colitis (UC). However, their clinical use is limited by poor homing to the colonic mucosa. Tongxie Yaofang (TXYF) is a traditional Chinese medicine formula. Our findings indicate that TXYF enhances the homing of BMSCs to the colonic mucosa and ameliorates symptoms of UC. This effect appears to involve modulation of the stromal cell-derived factor 1/C-X-C chemokine receptor type 4 axis. These findings suggest that TXYF may serve as an adjunct strategy to improve the efficacy of BMSCs-based therapy for UC.
Citation	Gong SS, Li ML, Liu L, Lv B. Tongxie Yaofang enhances the homing efficiency of exogenous bone marrow-derived mesenchymal stem cells to the colonic mucosa and alleviates ulcerative colitis. World J Stem Cells 2026; In press

Received	2026-01-26 06:58
Peer-Review Started	2026-01-26 07:03
First Decision by Editorial Office Director	2026-02-03 11:09
Return for Revision	2026-02-03 11:48
Revised	2026-02-15 12:15
Publication Fee Transferred	2026-02-21 06:33
Second Decision by Editor	2026-03-24 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-01 12:10
Articles in Press	2026-04-01 12:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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