Publication Name	World Journal of Gastroenterology
Manuscript ID	119263
Country	Latvia

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Disrupted coupling between ferritin and iron absorption in enteropathy-related anemia: Evidence for a dual-pathway model
Manuscript Source	Unsolicited Manuscript
All Author List	Olesja Basina, Jelena Derova, Nikola Krumina, Maksims Zolovs, Sandra Lejniece and Aleksejs Derovs
Funding Agency and Grant Number
Corresponding Author	Olesja Basina, Chief Physician, Doctorate Student, Lecturer, MD, VCA Gastroenterology and Endoscopy Department, VCA, Nicgales street 5, Riga LV1035, Riga, Latvia. olesja.basina@rsu.lv
Key Words	Iron deficiency; Enteropathy; Ferritin; Capsule endoscopy; Iron absorption; Fatigue; Functional Assessment of Chronic Illness Therapy; Pathway modeling
Core Tip	Iron deficiency anemia without overt gastrointestinal bleeding remains a diagnostic challenge, particularly in patients with suspected small-bowel disease. In this study, we integrated video capsule endoscopy findings with an oral iron absorption test, serum iron biomarkers, and fatigue scores. Our results demonstrate that enteropathy independently impairs intestinal iron absorption and alters ferritin levels, yet without a direct association between these two processes. This dissociation suggests that ferritin alone may not accurately reflect functional iron deficiency in enteropathy and highlights the importance of assessing small-bowel mucosal integrity in patients with unexplained anemia or fatigue.
Citation	Basina O, Derova J, Krumina N, Zolovs M, Lejniece S, Derovs A. Disrupted coupling between ferritin and iron absorption in enteropathy-related anemia: Evidence for a dual-pathway model. World J Gastroenterol 2026; In press

Received	2026-01-26 02:31
Peer-Review Started	2026-01-26 02:32
First Decision by Editorial Office Director	2026-02-28 08:09
Return for Revision	2026-02-28 08:09
Revised	2026-03-13 17:11
Publication Fee Transferred	2026-03-25 06:59
Second Decision by Editor	2026-04-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-22 07:43
Articles in Press	2026-04-22 07:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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