Publication Name	World Journal of Clinical Oncology
Manuscript ID	119275
Country	China

Category	Orthopedics
Manuscript Type	Basic Study
Article Title	Identification of SRSF2 as a potential immunodiagnostic biomarker for osteosarcoma: A study based on focused protein microarray
Manuscript Source	Unsolicited Manuscript
All Author List	Yan Ma, Lei Wan, Yong-Yong Zhang, Ya-Ge Luo, Ning Yang, Fei-Fei Pu, Malik Ihsan Ullah Khan, Man Liu, Jin-Shan Liu and Ji-Tian Li
Funding Agency and Grant Number	Funding Agency Grant Number China Association of Chinese Medicine Young Talent Support Program 2021-QNCRC2-A06 the Traditional Chinese Medicine Research in Henan Province 2023ZY2136 Research Project of China Information Association of Traditional Chinese Medicine CACMS-KY-2023030-2023030 Henan Province Collaborative Research Project on Traditional Chinese Medicine Science and Technology Special Program 2025LHZX5043
Corresponding Author	Ji-Tian Li, MD, PhD, Professor, Henan Provincial Health Commission Key Laboratory of Bone Metabolism and Analysis, Luoyang Orthopedic Hospital of Henan Province (Orthopedic Hospital of Henan Province), Henan University of Chinese Medicine, No. 100 Yongping Road, Zhengzhou 450046, Henan Province, China. jitianlee@hotmail.com
Key Words	Osteosarcoma; Tumor associated antigen; Protein microarray; Detection; SRSF2; Biomarker
Core Tip	Osteosarcoma (OS) is, a common malignant tumor, with no specific serological biomarker for early diagnosis. In this study, we focused on identifying novel autoantibodies against tumor associated antigens using the focused protein microarray based on cancer-driving genes for detecting OS. Three tumor associated antigens were identified through the focused protein microarray. Expression of these three autoantibodies was further detected by enzyme-linked immunosorbent assay, which was further validated by western blotting and immunohistochemistry. Serine/arginine-rich splicing factor 2 was identified as a potential serological biomarker for OS, and a possible supplementary screening approach.
Citation	Ma Y, Wan L, Zhang YY, Luo YG, Yang N, Pu FF, Khan MIU, Liu M, Liu JS, Li JT. Identification of SRSF2 as a potential immunodiagnostic biomarker for osteosarcoma: A study based on focused protein microarray. World J Clin Oncol 2026; In press

Received	2026-01-26 07:02
Peer-Review Started	2026-01-26 07:03
First Decision by Editorial Office Director	2026-01-29 08:40
Return for Revision	2026-01-29 08:40
Revised	2026-02-11 09:18
Publication Fee Transferred	2026-02-13 00:32
Second Decision by Editor	2026-03-26 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-26 07:15
Articles in Press	2026-03-26 07:15
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ISSN	2218-4333 (online)
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