Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	119293
Country	China

Category	Pharmacology & Pharmacy
Manuscript Type	Prospective Study
Article Title	Impact of oxiracetam on postoperative delirium in elderly patients undergoing laparoscopic gastrointestinal surgery
Manuscript Source	Unsolicited Manuscript
All Author List	Bao-Sheng Lv, Wei Wang, Mu Jin, Yan Ma, Jia-Lu Wang and Hui Gao
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Hebei Province H2021103001
Corresponding Author	Wei Wang, MD, Department of Neurology, Hebei Yanda Hospital, Yanjiao Development Zone, Langfang 065201, Hebei Province, China. ww19333643617@163.com
Key Words	Postoperative delirium; Aged; Oxiracetam; Laparoscopic surgery; Inflammation; Randomized controlled trial
Core Tip	Perioperative intravenous oxiracetam safely and effectively reduces the risk of postoperative delirium in elderly patients undergoing laparoscopic gastrointestinal surgery, and maintains postoperative cognitive functionality. Its protective effect likely involves multi-target mechanisms, including stabilization complex modulation of the systemic immune response, rather than dependence on simple suppression of a single inflammatory pathway. This study provides a foundation for the clinical application of oxiracetam as a perioperative brain protection strategy for elderly surgical patients.
Citation	Lv BS, Wang W, Jin M, Ma Y, Wang JL, Gao H. Impact of oxiracetam on postoperative delirium in elderly patients undergoing laparoscopic gastrointestinal surgery. World J Gastrointest Surg 2026; In press

Received	2026-01-27 07:03
Peer-Review Started	2026-01-27 07:04
First Decision by Editorial Office Director	2026-01-30 08:52
Return for Revision	2026-01-30 08:52
Revised	2026-02-12 02:36
Publication Fee Transferred	2026-02-14 02:15
Second Decision by Editor	2026-03-10 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-10 07:22
Articles in Press	2026-03-10 07:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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