Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	119296
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	Clinical applicability of synchronous vs sequential transarterial chemoembolization and microwave ablation in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Gao-Yi Ruan, Zheng Zhu, Zhen-Zhai Cai, Guang-Rong Lu and Qin-Jian Wang
Funding Agency and Grant Number	Funding Agency Grant Number the Natural Science Foundation of Wenzhou City Y20240207
Corresponding Author	Qin-Jian Wang, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Q, Wenzhou 325000, Zhejiang Province, China. 571924277@qq.com
Key Words	Hepatocellular carcinoma; Transarterial chemoembolization; Precision medicine; Sequential treatment; Clinical applicability
Core Tip	Combination of transarterial chemoembolization and microwave ablation is an effective locoregional treatment for hepatocellular carcinoma. Synchronous and sequential strategies show similar short-term efficacy and safety, but current evidence is limited by heterogeneity, non-standardized protocols, and insufficient long-term data. Synchronous therapy is suitable for small, solitary tumors with good liver function, whereas sequential therapy is better for large, multifocal tumors or impaired liver reserve. Individualized selection and future prospective, stratified, biomarker-driven studies are needed to optimize clinical practice.
Citation	Ruan GY, Zhu Z, Cai ZZ, Lu GR, Wang QJ. Clinical applicability of synchronous vs sequential transarterial chemoembolization and microwave ablation in hepatocellular carcinoma. World J Gastrointest Surg 2026; In press

Received	2026-01-26 01:52
Peer-Review Started	2026-01-26 01:53
First Decision by Editorial Office Director	2026-01-28 07:55
Return for Revision	2026-01-28 07:55
Revised	2026-02-01 05:46
Publication Fee Transferred
Second Decision by Editor	2026-05-19 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-19 06:09
Articles in Press	2026-05-19 06:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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