Publication Name	World Journal of Orthopedics
Manuscript ID	119301
Country	India

Category	Orthopedics
Manuscript Type	Systematic Reviews
Article Title	Extended antibiotic prophylaxis in primary total knee arthroplasty: A narrative review of current evidence and controversies
Manuscript Source	Invited Manuscript
All Author List	Tarun Jayakumar, Naveen Jeyaraman, Arulkumar Nallakumarasamy, Sathish Muthu and Madhan Jeyaraman
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com
Key Words	Periprosthetic joint infection; Antibiotics; Extended spectrum; Antimicrobial resistance; Antibiotic stewardship
Core Tip	Extended oral antibiotic prophylaxis after primary total knee arthroplasty has not demonstrated consistent benefit in reducing periprosthetic joint infection compared with standard ≤ 24-hour regimens. While early retrospective data suggested possible value in high-risk patients, larger studies and meta-analyses show no advantage and highlight antimicrobial resistance concerns. Current international guidelines recommend limiting prophylaxis to 24 hours, with future randomized trials needed to clarify extended oral antibiotic’s role in selected populations.
Citation	Jayakumar T, Jeyaraman N, Nallakumarasamy A, Muthu S, Jeyaraman M. Extended antibiotic prophylaxis in primary total knee arthroplasty: A narrative review of current evidence and controversies. World J Orthop 2026; In press

Received	2026-01-26 01:46
Peer-Review Started	2026-01-26 01:46
First Decision by Editorial Office Director	2026-01-30 09:05
Return for Revision	2026-01-30 09:05
Revised	2026-02-01 17:37
Publication Fee Transferred
Second Decision by Editor	2026-04-21 02:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-21 08:47
Articles in Press	2026-04-21 08:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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