Publication Name	World Journal of Cardiology
Manuscript ID	119321
Country	United States

Category	Research & Experimental Medicine
Manuscript Type	Minireviews
Article Title	Mechanistic convergence of exercise and mesenchymal stem cell-derived exosome signaling in isoproterenol-induced myocardial injury
Manuscript Source	Invited Manuscript
All Author List	Jacob Strouse, Stevenson Cottiere and Brandon Lucke-Wold
Funding Agency and Grant Number
Corresponding Author	Jacob Strouse, Doctorate Student, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th St AHC2, Miami, FL 33138, United States. jstro026@fiu.edu
Key Words	Myocardial ischemia; Isoproterenol; Mesenchymal stem cell; Exosomes; Nanoparticles; ERK; Exercise; AKT/mTOR
Core Tip	Exercise primes cardiomyocyte stress tolerance through ERK and PI3K/Akt/mTOR pathway activation, regulated autophagy, and mitochondrial preservation, while mesenchymal stem cell-derived exosomes reinforce these same survival networks via paracrine delivery of bioactive cargo. Integrating exercise conditioning with targeted, cell-free exosome-based strategies may overcome current therapeutic plateaus by enhancing biological engagement, improving myocardial resilience, and biasing post-ischemic remodeling toward adaptive recovery.
Citation	Strouse J, Cottiere S, Lucke-Wold B. Mechanistic convergence of exercise and mesenchymal stem cell-derived exosome signaling in isoproterenol-induced myocardial injury. World J Cardiol 2026; In press

Received	2026-02-02 01:26
Peer-Review Started	2026-02-02 01:28
First Decision by Editorial Office Director	2026-02-14 07:40
Return for Revision	2026-02-14 07:40
Revised	2026-03-05 04:44
Publication Fee Transferred
Second Decision by Editor	2026-04-10 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-10 04:03
Articles in Press	2026-04-10 04:03
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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