Publication Name	World Journal of Stem Cells
Manuscript ID	119325
DOI	10.4252/wjsc.119325
Country	China

Category	Obstetrics & Gynecology
Manuscript Type	Basic Study
Article Title	Therapeutic potential of umbilical cord-derived mesenchymal stem cells in ameliorating ovarian aging: Insights from single-cell analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Jin-Ning Zhang, Shuang Tian, Xin-Meng Guo, Qi Zhang, Jin Shang and Yuan-Qing Yao
Funding Agency and Grant Number
Corresponding Author	Yuan-Qing Yao, Senior Department of Obstetrics and Gynecology, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100010, China. yao_yuanqing@126.com
Key Words	Ovarian aging; Mesenchymal stem cells; Aged control; Single-cell RNA; Umbilical cord-derived mesenchymal stem cell
Core Tip	This study demonstrates that umbilical cord-derived mesenchymal stem cells (UCMSCs) effectively alleviate ovarian aging in aged mice and enhance oocyte quality. Single-cell transcriptomic analysis revealed that UCMSC treatment led to increased mitochondrial oxidative phosphorylation, elevated Klotho expression, and suppression of aging-related pathways. Additionally, UCMSCs improved intercellular communication within the ovary and influenced the developmental trajectory of granulosa cells. These findings elucidate the mechanisms underlying UCMSC-mediated ovarian rejuvenation and highlight their therapeutic potential for addressing age-related ovarian decline.
Citation	Zhang JN, Tian S, Guo XM, Zhang Q, Shang J, Yao YQ. Therapeutic potential of umbilical cord-derived mesenchymal stem cells in ameliorating ovarian aging: Insights from single-cell analysis. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.119325
PDF	119325-in-press.pdf

Received	2026-04-22 10:16
Peer-Review Started	2026-04-22 10:16
First Decision by Editorial Office Director	2026-05-15 10:08
Return for Revision	2026-05-15 10:08
Revised	2026-06-16 15:27
Publication Fee Transferred	2026-06-29 01:30
Second Decision by Editor	2026-07-27 02:55
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-20 09:34
Articles in Press	2026-10-20 09:34
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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