Publication Name	World Journal of Gastroenterology
Manuscript ID	119326
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Outpatient visit frequency in patients with overlapping non-erosive reflux disease and epigastric pain syndrome: A multicenter study
Manuscript Source	Unsolicited Manuscript
All Author List	Mi Lv, Xin Liu, Kai-Yue Huang, Lu-Si Xu, Hui Che, Meng-Xi Yao and Feng-Yun Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82374434, 82174363 Youth Science Foundation Project of the National Natural Science Foundation of China 82205104 Excellent Young Scientific and Technological Talent Training Program of the Fundamental Scientific Research Business Expenses of China Academy of Chinese Medical Sciences ZZ16-YQ-002
Corresponding Author	Feng-Yun Wang, Adjunct Professor, Chief Physician, Director, Full Professor, MD, Professor, Institute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, No. 1 Xiyuan Playground, Haidian District, Beijing 100091, China. 18810631761@163.com
Key Words	Non-erosive reflux disease; Epigastric pain syndrome; Biopsychosocial model; Outpatient visits frequency; Cross-sectional study
Core Tip	In this first large-scale multicenter study of overlapping non-erosive reflux disease and epigastric pain syndrome in China, frequent healthcare visits were driven not by symptom severity, but by a profile combining chronicity, psychological distress, and complex medication patterns. A striking interaction between proton pump inhibitor and Chinese herbal medicine use identified a high-need subgroup. These findings highlight the importance of an integrated, psychosomatic approach addressing both peripheral and central mechanisms to reduce the healthcare burden in this population.
Citation	Lv M, Liu X, Huang KY, Xu LS, Che H, Yao MX, Wang FY. Outpatient visit frequency in patients with overlapping non-erosive reflux disease and epigastric pain syndrome: A multicenter study. World J Gastroenterol 2026; In press

Received	2026-01-26 06:22
Peer-Review Started	2026-01-26 06:26
First Decision by Editorial Office Director	2026-02-13 08:14
Return for Revision	2026-02-13 08:14
Revised	2026-02-26 06:44
Publication Fee Transferred	2026-03-03 09:55
Second Decision by Editor	2026-04-01 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-01 11:15
Articles in Press	2026-04-01 11:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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