Publication Name	World Journal of Gastroenterology
Manuscript ID	119352
Country	Romania

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Application of spatial omics, multi-omics, and artificial intelligence in inflammatory bowel disease: Current applications and emerging opportunities
Manuscript Source	Unsolicited Manuscript
All Author List	Charles Adolfu Shirima, Gibson Albert Sabuholo, Lucia Bubulac, Priya Patel and Gratiela Gradisteanu Pircalabioru
Funding Agency and Grant Number
Corresponding Author	Gratiela Gradisteanu Pircalabioru, Academic Fellow, Associate Professor, Department of Botany and Microbiology, Faculty of Biology, University of Bucharest, sos Panduri 90, Bucharest 030014, Romania. gratiela.gradisteanu@icub.unibuc.ro
Key Words	Inflammatory bowel disease; Multi-omics; Crohn’s disease; Artificial intelligence; Spatial-omics; Ulcerative colitis; Microbiota
Core Tip	Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, arises from complex, spatially organized interactions between host genetics, immune responses, epithelial integrity, and the intestinal microbiota. Emerging multi-omics and spatial-omics technologies now enable high-resolution, tissue-context-preserved profiling of these processes, revealing disease-defining cellular niches and host-microbiome interactions. Artificial intelligence (AI) provides a critical framework for integrating high-dimensional datasets, uncovering non-linear relationships, and translating molecular complexity into clinically actionable insights. The convergence of multi-omics, spatial-omics, and AI holds strong promise for precision medicine in IBD, enabling improved disease stratification, identification of spatial biomarkers for progression and cancer risk, and the development of next-generation, non-animal disease models.
Citation	Shirima CA, Sabuholo GA, Bubulac L, Patel P, Gradisteanu Pircalabioru G. Application of spatial omics, multi-omics, and artificial intelligence in inflammatory bowel disease: Current applications and emerging opportunities. World J Gastroenterol 2026; In press

Received	2026-01-26 03:02
Peer-Review Started	2026-01-26 03:13
First Decision by Editorial Office Director	2026-02-09 09:50
Return for Revision	2026-02-09 09:50
Revised	2026-02-20 21:51
Publication Fee Transferred
Second Decision by Editor	2026-05-09 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-09 11:25
Articles in Press	2026-05-09 11:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com