Publication Name	World Journal of Gastroenterology
Manuscript ID	119364
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Novel inflammation-based model for postoperative early recurrence prediction of hepatitis B virus-related hepatocellular carcinoma ≤ 5 cm
Manuscript Source	Unsolicited Manuscript
All Author List	Tian-Xing Dai, Jing Li, Hua Li and Guo-Ying Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82303859 the Scientific and Technological Planning Project of Guangzhou City, China 2024A04J3543 the Scientific and Technological Planning Project of Guangzhou City, China 2025A03J4318
Corresponding Author	Guo-Ying Wang, Chief Physician, PhD, Professor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiangxi Road, Guangzhou 510120, Guangdong Province, China. wanggy3@126.com
Key Words	Hepatocellular carcinoma; Inflammation; Prognostic model; Recurrence-free survival; Nomogram
Core Tip	In patients with hepatitis B virus-related hepatocellular carcinoma with tumors ≤ 5 cm, early recurrence (≤ 2 years) accounted for 74.7% of all recurrences. An inflammation-related score model was developed based on four key indices (glutamyl transpeptidase-to-platelet ratio, prognostic nutritional index, albumin-bilirubin index, and aminotransferase to lymphocyte ratio index), and integrated with clinicopathological factors into a novel nomogram. This model demonstrated superior prognostic accuracy and clinical utility in predicting early recurrence compared to conventional staging systems, and effectively identified high-risk patients with significantly poorer outcomes.
Citation	Dai TX, Li J, Li H, Wang GY. Novel inflammation-based model for postoperative early recurrence prediction of hepatitis B virus-related hepatocellular carcinoma ≤ 5 cm. World J Gastroenterol 2026; In press

Received	2026-01-26 06:13
Peer-Review Started	2026-01-26 06:14
First Decision by Editorial Office Director	2026-02-09 09:52
Return for Revision	2026-02-09 09:52
Revised	2026-02-23 09:33
Publication Fee Transferred
Second Decision by Editor	2026-03-10 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-10 08:58
Articles in Press	2026-03-10 08:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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