Publication Name	World Journal of Radiology
Manuscript ID	119372
Country	Japan

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Minireviews
Article Title	Molecular basis of radiation resistance in tardigrades and the medical implications
Manuscript Source	Invited Manuscript
All Author List	Hiroki Goto, Mariko Takano and Nuchjira Takheaw
Funding Agency and Grant Number
Corresponding Author	Hiroki Goto, Associate Professor, MD, PhD, Division of Radioisotope and Tumor Pathobiology, Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-Ku, Kumamoto 860-0811, Japan. hgoto20@kumamoto-u.ac.jp
Key Words	Tardigrade; Damage suppressor; Cryptobiosis; Ionizing radiation; Reactive oxygen species
Core Tip	Tardigrades exhibit extraordinary resistance to ionizing and ultraviolet radiation. Among the tardigrade-derived molecules linked to this resilience, damage suppressor binds to chromatin and mitigates both hydroxyl-radical-induced DNA breaks and ultraviolet-induced pyrimidine dimers. Recent studies have demonstrated that damage suppressor expression in mammalian cells reduces γ-H2AX foci by approximately 40% and prolongs cellular survival after irradiation. In this minireview, we highlight recent advances in understanding tardigrade radiation resistance and explore potential clinical applications for managing radiation-induced cellular injury.
Citation	Goto H, Takano M, Takheaw N. Molecular basis of radiation resistance in tardigrades and the medical implications. World J Radiol 2026; In press

Received	2026-01-26 00:46
Peer-Review Started	2026-01-26 00:47
First Decision by Editorial Office Director	2026-03-02 08:49
Return for Revision	2026-03-02 08:49
Revised	2026-03-10 14:09
Publication Fee Transferred
Second Decision by Editor	2026-04-08 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-08 10:29
Articles in Press	2026-04-08 10:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8470 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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