Publication Name	World Journal of Gastroenterology
Manuscript ID	119374
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Enhancing delivery of doxorubicin using triolein emulsion in rabbit VX2 liver tumor model
Manuscript Source	Unsolicited Manuscript
All Author List	Yong-Woo Kim, Hak Jin Kim, Seon Hee Choi and Mi Sook Yun
Funding Agency and Grant Number
Corresponding Author	Hak Jin Kim, PhD, Professor, Department of Radiology, Biomedical Research Institute, Pusan National University Hospital, Pusan National University College of Medicine, 179 Gudeok-ro, Seo-gu, Busan 49241, South Korea. hakjink@pusan.ac.kr
Key Words	Transcatheter arterial chemoembolization; Hepatocellular carcinoma; VX2 tumor; Liver; Doxorubicin; Triolein emulsion
Core Tip	The infusion of triolein emulsion into the hepatic arteries increased the liver vascular permeability in the sinusoidal capillaries by transiently disrupting endothelial barriers, leading to a minimal transient decrease in liver function without specific histopathological changes in the rabbit livers. Consequently, any triolein-induced endothelial loosening can substantially enhance drug extravasation into liver tissue. This study aimed to evaluate the antitumor effects of doxorubicin by comparing the changes in tumor volume and the growth ratios between the triolein emulsion with doxorubicin and normal saline with doxorubicin groups via a hepatic arterial infusion in a rabbit liver VX2 tumor model.
Citation	Kim YW, Kim HJ, Choi SH, Yun MS. Enhancing delivery of doxorubicin using triolein emulsion in rabbit VX2 liver tumor model. World J Gastroenterol 2026; In press

Received	2026-01-27 06:02
Peer-Review Started	2026-01-27 06:04
First Decision by Editorial Office Director	2026-02-04 10:11
Return for Revision	2026-02-04 10:11
Revised	2026-02-13 22:56
Publication Fee Transferred	2026-02-19 13:43
Second Decision by Editor	2026-03-26 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-26 05:54
Articles in Press	2026-03-26 05:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com