Publication Name	World Journal of Clinical Cases
Manuscript ID	119413
Country	Italy

Category	Ophthalmology
Manuscript Type	Minireviews
Article Title	Gene therapy for diabetic retinopathy
Manuscript Source	Invited Manuscript
All Author List	Matteo Capobianco, Simonetta Gaia Nicolosi, Francesco Cappellani, Marieme Khouyyi, Fabiana D’Esposito, Caterina Gagliano and Marco Zeppieri
Funding Agency and Grant Number
Corresponding Author	Marco Zeppieri, Consultant, MD, PhD, Postdoc, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Key Words	Diabetic retinopathy; Diabetic macular edema; Gene therapy; Retinal biofactory; Adeno-associated virus; Suprachoroidal delivery; Inflammation; Neurovascular unit; Genome editing
Core Tip	Gene therapy for diabetic retinopathy is developing as a method to diminish the want for regular intravitreal injections by offering prolonged intraocular modulation of disease pathways. Extensive experience with age-related macular degeneration provides compelling clinical evidence that sustained suppression of pathological vascular signaling is feasible, while preliminary studies on diabetic retinopathy are evaluating the potential for similar durability within the inflammatory diabetic retinal milieu. Significant obstacles to translation encompass delivery- and dose-associated intraocular inflammation, ambiguity concerning long-term efficacy and the practicality of repeated dosage, as well as the necessity for stringent patient selection and monitoring.
Citation	Capobianco M, Nicolosi SG, Cappellani F, Khouyyi M, D’Esposito F, Gagliano C, Zeppieri M. Gene therapy for diabetic retinopathy. World J Clin Cases 2026; In press

Received	2026-01-27 05:47
Peer-Review Started	2026-01-27 05:50
First Decision by Editorial Office Director	2026-02-28 06:48
Return for Revision	2026-02-28 06:48
Revised	2026-02-28 09:36
Publication Fee Transferred
Second Decision by Editor	2026-03-11 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-11 08:23
Articles in Press	2026-03-11 08:23
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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