Publication Name	World Journal of Gastroenterology
Manuscript ID	119419
Country	China

Category	Immunology
Manuscript Type	Minireviews
Article Title	Insights into the pathogenic roles and targeted therapy of neutrophil extracellular traps in inflammatory bowel disease
Manuscript Source	Unsolicited Manuscript
All Author List	Ying Qi, Liang Ma, Yin Zhang, Yi Liu, Min Su, Ting-Ting Cai, Mei Wang and Ke-Wen Sun
Funding Agency and Grant Number	Funding Agency Grant Number Changzhou Applied Basic Research Program No. CJ20220091
Corresponding Author	Ke-Wen Sun, Chief Physician, Department of Gastroenterology, The First People’s Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, No. 185 Juqian Street, Tianning District, Changzhou 213004, Jiangsu Province, China. sunkewen0727@suda.edu.cn
Key Words	Inflammatory bowel disease; Neutrophil extracellular traps; Mucosal immunity; Mechanism; Clinical translation
Core Tip	Neutrophil extracellular traps (NETs), while essential for pathogen clearance, act as a double-edged sword in inflammatory bowel diseases (IBDs). Excessive accumulation of NETs has been confirmed in IBD patients and colitis mouse model. NET components can exacerbate chronic intestinal inflammation, destroy intestinal mucosal barrier and aggravate tissue damage, promote thrombosis and colitis-associated cancer. Consequently, therapeutic strategies targeting NET formation or promoting NET degradation are emerging as promising avenues to restore intestinal mucosal homeostasis in IBD.
Citation	Qi Y, Ma L, Zhang Y, Liu Y, Su M, Cai TT, Wang M, Sun KW. Insights into the pathogenic roles and targeted therapy of neutrophil extracellular traps in inflammatory bowel disease. World J Gastroenterol 2026; In press

Received	2026-02-02 02:47
Peer-Review Started	2026-02-02 02:48
First Decision by Editorial Office Director	2026-02-10 10:54
Return for Revision	2026-02-10 10:54
Revised	2026-02-23 15:04
Publication Fee Transferred	2026-02-25 11:54
Second Decision by Editor	2026-03-17 03:05
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-17 09:54
Articles in Press	2026-03-17 09:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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