| Category |
Pediatrics |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Clinical and laboratory manifestations and treatment of children with different variants of the TNFRSF1A gene
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ekaterina I Alexeeva, Meiri Sh Shingarova, Tatyana M Dvoryakovskaya, Ksenia B Isaeva, Aleksandra M Chomakhidze, Anna N Fetisova, Kristina V Chibisova, Elizaveta A Krekhova, Ivan A Kriulin, Tatyana Y Kriulina, Irina T Tsulukiya, Maria S Botova, Natalya M Kondratyeva, Maria Y Kokina, Anastasia A Makunc, Narvik A Dostiev, Kirill V Savostyanov, Aleksandr A Pushkov, Ilya S Zhanin, Dmitry S Demyanov and Mikhail M Kostik |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Mikhail M Kostik, MD, PhD, Professor, Hospital Pediatry, Saint Petersburg State Pediatric Medical University, Lytovskaya 2, Saint Petersburg 194100, Sankt-Peterburg, Russia. kost-mikhail@yandex.ru |
| Key Words |
Autoinflammatory diseases; Genetic; Biological disease modifying antirheumatic drugs; Rheumatology; Pediatric; Children; TNFRSF1A gene |
| Core Tip |
The study is devoted to a comparative analysis of clinical and laboratory data from patients with TNFRSF1A variants and from patients with systemic juvenile idiopathic arthritis without variants in genes associated with autoinflammation, as well as an analysis of drug therapy. As a result of the study, the phenotypic features of patients with tumor necrosis factor receptor associated periodic syndrome were identified, allowing them to suspect the disease before receiving genetic test results and to identify the most effective drugs for their treatment. |
| Citation |
Alexeeva EI, Shingarova MS, Dvoryakovskaya TM, Isaeva KB, Chomakhidze AM, Anna N Fetisova, Chibisova KV, Krekhova EA, Kriulin IA, Kriulina TY, Tsulukiya IT, Botova MS, Kondratyeva NM, Kokina MY, Makunc AA, Dostiev NA, Savostyanov KV, Pushkov AA, Zhanin IS, Demyanov DS, Kostik MM. Clinical and laboratory manifestations and treatment of children with different variants of the TNFRSF1A gene. World J Clin Pediatr 2026; In press |
