Publication Name	World Journal of Experimental Medicine
Manuscript ID	119440
Country	Saudi Arabia

Category	Urology & Nephrology
Manuscript Type	Retrospective Study
Article Title	Forgotten compartment: Impact of tubulointerstitial inflammation and damage on renal outcomes in lupus nephritis from Saudi Arabia
Manuscript Source	Invited Manuscript
All Author List	Muhammad Abdul Mabood Khalil, Nihal Mohammed Sadagah, Hinda Hassan Khideer Mahmood, Fadel Alrowaie, Abdullah Mohammed Almansour, Rayan Mohammed H Alghamdi, Lama Alghamdi, Rawan A Al-Ghamdi, Ammar Elgadi and Salem H Al-Qurashi
Funding Agency and Grant Number
Corresponding Author	Muhammad Abdul Mabood Khalil, Center of Renal Diseases and Transplantation, King Fahad Armed Forces Hospital, Al Kurnaysh Br Road, Al Andalus, Jeddah 23311, Makkah al Mukarramah, Saudi Arabia. doctorkhalil1975@hotmail.com
Key Words	Lupus nephritis; Tubulointerstitial inflammation; Tubulointerstitial damage; Renal biopsy; Renal outcomes; Prognosis; Saudi Arabia
Core Tip	Although current lupus nephritis (LN) classifications focus mainly on glomerular lesions, tubulointerstitial involvement is frequent and clinically relevant. In this Saudi cohort, the presence of combined tubulointerstitial inflammation and damage was associated with proliferative disease, higher activity and chronicity scores, and poorer renal outcomes. These patients achieved remission more slowly and less often during follow-up. Baseline kidney function, systemic inflammation, and selected histologic features further influenced prognosis. Detailed assessment of the tubulointerstitial compartment may therefore add meaningful prognostic information in LN.
Citation	Khalil MAM, Sadagah NM, Mahmood HHK, Alrowaie F, Almansour AM, Alghamdi RMH, Alghamdi L, A Al-Ghamdi R, Elgadi A, Al-Qurashi SH. Forgotten compartment: Impact of tubulointerstitial inflammation and damage on renal outcomes in lupus nephritis from Saudi Arabia. World J Exp Med 2026; In press

Received	2026-01-28 03:47
Peer-Review Started	2026-01-28 03:48
First Decision by Editorial Office Director	2026-02-25 08:30
Return for Revision	2026-02-25 08:30
Revised	2026-03-29 19:40
Publication Fee Transferred
Second Decision by Editor	2026-04-15 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-15 07:47
Articles in Press	2026-04-15 07:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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