Publication Name	World Journal of Gastroenterology
Manuscript ID	119442
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Fibrosis index nine superiority for cirrhosis in hypopituitarism: Clinical validation of endocrine liver triage tool
Manuscript Source	Unsolicited Manuscript
All Author List	Ting Li, Xi Wang, Min Nie, Qin Han, Xue-Yan Wu and Jiang-Feng Mao
Funding Agency and Grant Number
Corresponding Author	Jiang-Feng Mao, MD, Professor, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing, China, Beijing 100730, China. maojf@pumch.cn
Key Words	Hypopituitarism; Liver fibrosis; Cirrhosis; Non-invasive test; Craniopharyngioma; Fibrosis-9 index; Fibrosis-4 index; Aspartate aminotransferase-to-platelet ratio index; Liver stiffness measurement; Metabolic dysfunction-associated steatotic liver disease
Core Tip	Patients with hypopituitarism are at high risk for rapidly progressive metabolic liver disease, yet traditional non-invasive tests often lack accuracy in this specific endocrine-mediated context. This study provides the first clinical validation of the fibrosis-9 (FIB-9) index in hypopituitary patients. Our findings reveal that FIB-9 (area under the receiver operating characteristic curve = 0.941) significantly outperforms aspartate aminotransferase-to-platelet ratio index, fibrosis-4, and conventional serum markers in identifying cirrhosis. Using an optimal cutoff of 1.748, FIB-9 serves as a highly reliable triage tool, enabling clinicians to accurately identify high-risk patients for advanced liver assessment while sparing others from unnecessary testing.
Citation	Li T, Wang X, Nie M, Han Q, Wu XY, Mao JF. Fibrosis index nine superiority for cirrhosis in hypopituitarism: Clinical validation of endocrine liver triage tool. World J Gastroenterol 2026; In press

Received	2026-01-28 06:43
Peer-Review Started	2026-01-28 06:44
First Decision by Editorial Office Director	2026-02-26 07:57
Return for Revision	2026-02-26 07:57
Revised	2026-03-19 03:13
Publication Fee Transferred	2026-03-20 02:39
Second Decision by Editor	2026-04-02 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-02 09:02
Articles in Press	2026-04-02 09:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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