Publication Name	World Journal of Gastroenterology
Manuscript ID	119462
Country	Viet Nam

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	Biosimilars in inflammatory bowel disease: Beyond evidence, toward trust and implementation
Manuscript Source	Invited Manuscript
All Author List	Chuong Dinh Nguyen and Luan Minh Dang
Funding Agency and Grant Number
Corresponding Author	Luan Minh Dang, Lecturer, MD, Department of Gastroenterology, University Medical Center, No. 215 Hong Bang Street, Cho Lon Ward, Ho Chi Minh City 700000, Viet Nam. luan.dm@umc.edu.vn
Key Words	Biosimilars; Inflammatory bowel disease; Nocebo effect; Biologic switching; Health equity
Core Tip	Biosimilars in inflammatory bowel disease have moved beyond a narrow question of pharmacological equivalence. Although current evidence supports their efficacy, safety, and use across multiple clinical scenarios, adoption remains limited by nocebo-related discontinuation, physician hesitation, and system-level implementation barriers. This opinion review synthesizes current evidence, examines persistent controversies, and proposes a pragmatic 5-step framework for biosimilar initiation or switching in routine care. It also highlights the special challenges of resource-limited settings and introduces the concept of a “nocebo-prone environment” as a practical lens for understanding barriers to equitable biosimilar integration.
Citation	Nguyen CD, Dang LM. Biosimilars in inflammatory bowel disease: Beyond evidence, toward trust and implementation. World J Gastroenterol 2026; In press

Received	2026-01-28 00:46
Peer-Review Started	2026-01-28 00:46
First Decision by Editorial Office Director	2026-02-14 07:50
Return for Revision	2026-02-14 07:50
Revised	2026-02-15 03:04
Publication Fee Transferred
Second Decision by Editor	2026-04-08 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-08 08:04
Articles in Press	2026-04-08 08:04
Edit the Manuscript by Language Editor	2026-04-09 13:54
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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