Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	119473
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Polyposis in Lynch syndrome: A retrospective study
Manuscript Source	Unsolicited Manuscript
All Author List	Nadeen Sarsour, Eve Karloski, Beth Dudley, Shikhar Uttam, Brenda Diergaarde and Randall E Brand
Funding Agency and Grant Number
Corresponding Author	Randall E Brand, Department of Medicine, University of Pittsburgh, 200 Lorthop St., Pittsburgh, PA 15213, United States. brandre@upmc.edu
Key Words	Colorectal cancer; Polyposis; Lynch syndrome; Hereditary colon cancer; Genetics
Core Tip	The purpose of this paper is to further describe and investigate polyposis (≥ 10 lifetime adenomas) in patients with a diagnosis of Lynch syndrome (LS). Previously known as hereditary nonpolyposis syndrome, more data has emerged described polyposis occurring in these patients. We used a registry of patients with LS at our institution to find possible associations and commonalities among patients who had ≥ 10 lifetime adenomas in order to help determine which of these high-risk patients may be at higher risk for developing adenomas. We discovered that in our cohort, patients with polyposis more commonly had pathogenic variants in the MSH2 and MSH6 genes.
Citation	Sarsour N, Karloski E, Dudley B, Uttam S, Diergaarde B, Brand RE. Polyposis in Lynch syndrome: A retrospective study. World J Gastrointest Endosc 2026; In press

Received	2026-01-28 03:15
Peer-Review Started	2026-01-28 03:20
First Decision by Editorial Office Director	2026-02-26 07:59
Return for Revision	2026-02-28 02:29
Revised	2026-03-11 18:56
Publication Fee Transferred	2026-03-18 14:31
Second Decision by Editor	2026-05-08 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-08 08:09
Articles in Press	2026-05-08 08:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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