Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	119474
Country	Russia

Category	Cell & Tissue Engineering
Manuscript Type	Opinion Review
Article Title	Integrin-driven differences in extracellular matrix regulation of 3D-cultured tumor cells
Manuscript Source	Unsolicited Manuscript
All Author List	Ilya Klabukov, Daria Eygel and Denis S Baranovskii
Funding Agency and Grant Number
Corresponding Author	Ilya Klabukov, Associate Professor, Head, PhD, Department of Regenerative Medicine, National Medical Research Radiological Center, 4 Koroleva Street, Obninsk 249036, Kaluzhskaya Oblast’, Russia. ilya.klabukov@gmail.com
Key Words	Cancer; Cell regulation; Epithelial-mesenchymal transition; Extracellular matrix; Integrins; Spheroids; Tumor microenvironment
Core Tip	Differences in gene regulation between 3D-cultured mesenchymal and epithelial cells extend beyond the epithelial-mesenchymal transition and influence how tumor cells interact with a newly synthesized extracellular matrix. Regulation of integrin density and spatial distribution appears to play a central role in mediating cell-extracellular matrix interactions and may explain the distinct behaviors observed in tumor tissue models between different cell responses.
Citation	Klabukov I, Eygel D, Baranovskii DS. Integrin-driven differences in extracellular matrix regulation of 3D-cultured tumor cells. World J Gastrointest Oncol 2026; In press

Received	2026-01-28 03:12
Peer-Review Started	2026-01-28 03:20
First Decision by Editorial Office Director	2026-02-10 09:02
Return for Revision	2026-02-10 09:02
Revised	2026-02-18 06:58
Publication Fee Transferred
Second Decision by Editor	2026-05-14 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-14 08:26
Articles in Press	2026-05-14 08:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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