Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	119494
Country	China

Category	Anesthesiology
Manuscript Type	Clinical Trials Study
Article Title	Effects of esketamine on perioperative renal injury in paediatric patients undergoing living donor liver transplantation
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Xia Li, Gui-Zhu Cao, Yi-Qi Weng, Ai-Li Dong, Wei Gao, Min Zhu, Lu Che and Wen-Li Yu
Funding Agency and Grant Number	Funding Agency Grant Number Research Fund for Liquid Therapy in Anesthesiology Medicine YLGX-MZ-2022008 the Tianjin Key Clinical Speciality (Anaesthesiology) Construction Project the Tianjin Key Medical Construction Project TJYXZDXK-3-022C
Corresponding Author	Wen-Li Yu, Department of Anaesthesiology, Tianjin First Central Hospital, No. 24, Fukang Road, Nankai District, Tianjin 300192, Nankai District, China. 5020201005@nankai.edu.cn
Key Words	Esketamine; Paediatric living-donor liver transplantation; Acute kidney injury; Ischaemia-reperfusion injury; Renal protection; Inflammatory factors; Paediatric anaesthesia
Core Tip	This randomized controlled trial demonstrates that, compared with the control group, intraoperative esketamine administration significantly attenuates the increase in serum creatinine levels following ischemia-reperfusion injury and attenuates the systemic inflammatory response in pediatric patients undergoing living donor liver transplantation. The renoprotective effects are mediated by the suppression of tumour necrosis factor-α, interleukin-18, and neutrophil gelatinase-associated lipocalin, alongside hemodynamic stabilization. Esketamine may be considered as a component of anesthetic management to mitigate perioperative renal injury in this high-risk population.
Citation	Li HX, Cao GZ, Weng YQ, Dong AL, Gao W, Zhu M, Che L, Yu WL. Effects of esketamine on perioperative renal injury in paediatric patients undergoing living donor liver transplantation. World J Gastrointest Surg 2026; In press

Received	2026-01-29 02:56
Peer-Review Started	2026-01-29 02:57
First Decision by Editorial Office Director	2026-02-14 07:25
Return for Revision	2026-02-14 07:25
Revised	2026-03-04 11:53
Publication Fee Transferred	2026-03-08 13:33
Second Decision by Editor	2026-03-25 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-25 06:08
Articles in Press	2026-03-25 06:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com