Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	119506
Country	Thailand

Category	Pediatrics
Manuscript Type	Retrospective Study
Article Title	Sirolimus for the treatment of vascular tumors and malformations in children: A 10-year single-institution retrospective study
Manuscript Source	Invited Manuscript
All Author List	Nattaporn Thongngam, Lalita Sathitsamitphong, Wipawee Morakote, Supapitch Chanthong, Supawadee Maneekesorn, Rungrote Natesirinilkul, Pimlak Charoenkwan and Chane Choed-Amphai
Funding Agency and Grant Number
Corresponding Author	Chane Choed-Amphai, Assistant Professor, MD, PhD, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, No. 110 Intawarorot Road, Sriphum, Muang, Chiang Mai 50200, Thailand. chane.c@cmu.ac.th
Key Words	Sirolimus; Vascular anomalies; Vascular malformations; Vascular tumors; Children
Core Tip	Sirolimus is increasingly used as targeted therapy for pediatric vascular anomalies, yet real-world clinical data remain limited. In this retrospective study of children with vascular tumors and malformations, sirolimus demonstrated a high response rate and an acceptable safety profile across diverse disease subtypes. Rapid resolution of Kasabach-Merritt phenomenon was observed in patients with kaposiform hemangioendothelioma receiving combination therapy. However, disease progression occurred after treatment discontinuation, highlighting the need for careful post-therapy monitoring. These findings support sirolimus as an effective treatment option in refractory or unresectable pediatric vascular anomalies and emphasize the importance of optimizing treatment duration and follow-up strategies.
Citation	Thongngam N, Sathitsamitphong L, Morakote W, Chanthong S, Maneekesorn S, Natesirinilkul R, Charoenkwan P, Choed-Amphai C. Sirolimus for the treatment of vascular tumors and malformations in children: A 10-year single-institution retrospective study. World J Clin Pediatr 2026; In press

Received	2026-01-30 00:28
Peer-Review Started	2026-01-30 00:31
First Decision by Editorial Office Director	2026-02-12 08:24
Return for Revision	2026-02-12 08:24
Revised	2026-03-13 01:37
Publication Fee Transferred
Second Decision by Editor	2026-04-15 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-15 03:59
Articles in Press	2026-04-15 03:59
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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