Publication Name	World Journal of Cardiology
Manuscript ID	119513
Country	Indonesia

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Letter to the Editor
Article Title	Significance of flow mediated dilation in evaluating endothelial dysfunction in vasospastic angina
Manuscript Source	Invited Manuscript
All Author List	Wilbert Huang
Funding Agency and Grant Number
Corresponding Author	Wilbert Huang, MD, Senior Research Fellow, Faculty of Medicine, University of Padjadjaran, Jl. Dipatiukur No. 35, Bandung 40416, West Java, Indonesia. wilberthuang67@gmail.com
Key Words	Flow mediated dilation; Vasospastic angina; Endothelial dysfunction; Coronary artery disease; Prognosis
Core Tip	This study emphasizes the prognostic importance of endothelial-dependent vasodilation assessed by flow-mediated dilation (FMD) in patients with vasospastic angina. Unlike nitroglycerin-induced dilation, FMD was independently associated with major adverse cardiovascular events, underscoring the pivotal role of endothelial dysfunction rather than vascular smooth muscle impairment. Careful model construction avoided overfitting despite limited events. Given its non-invasive nature, FMD may serve as a valuable risk-stratification and potentially diagnostic tool in vasospastic angina, warranting further prospective validation.
Citation	Huang W. Significance of flow mediated dilation in evaluating endothelial dysfunction in vasospastic angina. World J Cardiol 2026; In press

Received	2026-01-30 00:25
Peer-Review Started	2026-01-30 00:31
First Decision by Editorial Office Director	2026-02-02 08:58
Return for Revision	2026-02-02 08:58
Revised	2026-02-04 15:23
Publication Fee Transferred
Second Decision by Editor	2026-03-10 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-10 11:06
Articles in Press	2026-03-10 11:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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